Since Dr. Kelso quit, things have changed at Sacred Heart. Namely, Dr Cox has been made Chief of Medicine but he doesn't want to deal with all the paperwork, including signing a settlement form from a drug company whose drug Plomox has been linked to deaths in diabetic patients. Meanwhile, with Carla's blessing, Turk has decided to get a prosthetic testicle. Janitor exercises his democratic flag planting rights and claims Kelso's former office in the name of the newly formed Brain Trust, of which he has assumed leadership over fellow members Doug, Todd and Ted.
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Jordan is irate, demanding updates every fifteen minutes on her daughter's surgery, or she'll have Chief Dr. Cox exercise his new power and fire the nurse. Meanwhile Ted strides into Cox's sight, introducing himself as the new Chief's invaluable right-hand man. Inundated with paperwork, Cox tries him out, giving him the lawsuit papers to review. Elliot decides to search for an old patient to whom she prescribed Plomox a year ago, and J.D. gives her a ride so he can pick Sam up from daycare.
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To mark the first night alone since having the baby, Turk and Carla pop a bottle of bubbly, but the cork misfires, hitting Turk in the groin. While Ted is on a coffee run for Cox, Janitor stops him and tells him to be a man and show Cox who's the boss. Ted decides to make a stand and wins a small victory. After the champagne incident, Turk gets his remaining testicle examined by a doctor, who gives him a clean bill of health. Carla, however, insists Turk wear bubble wrap in his boxers to protect his groin and make sure they can have another baby. Elliot has arranged a meeting with her former patient. As she waits with J.D. he admits to her she's not as much fun as Turk. Elliot plays a practical joke on a fast food restaurant manager to prove to J.D. she's as much of a goof as Turk.
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Janitor orders the Brain Trust to do his cleaning and Ted leads a revolt, forming his own Brain Bunch. Elliot's prank backfires and the cops are called in when the manager is kidnapped from the restaurant. Waiting for his daughter's surgery to end, Cox is overwhelmed. He has to deal with Turk admitting he's not ready for another baby with Carla, Elliot being unable to find her patient, and Ted finding his fighting spirit, as well as being summoned to the board meeting... again!
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J.D. asks if Carla wants a baby so bad why is she making Turk have potentially harmful surgery to get a fake testicle and Turk admits he's the one who wants the fake swinger, not Carla. Still inundated with paperwork and chaos, Cox is finally able to escape all the harassment from Jordan when Jenny's surgery finishes.
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J.D. asks Elliot if the real reason she's hunting for her former patient is fear that her prescription might have killed him. He then tells her the Plomax didn't kill him, the guy was hit by a truck. To make up for saying she wasn't as much fun as Turk, he asks if she'd like to join him and Sam for their afternoon latte. While they play happy families, Carla and Turk make up and the Janitor's Brain Trust brings Ted back into the fold, letting him choose their business focus: a card game.
As Doug wheels a body bag out and J.D. pushes in a new patient on a wheelchair, Kelso tells all the staff about his new rule: anyone who doesn't go home after their twelve-hour shift will be suspended and docked one day's pay. Elsewhere, Elliot is stumped when she can't uncover what is wrong with her new patient Marion. As two interns play diagnosis Jeopardy, J.D. complains to Dr. Cox that a few months earlier Elliot tried to kiss him and now she's saying J.D. was the one trying to kiss her. Cox is a stone wall, getting up to leave before his good day gets any worse. By the time Cox gets home to Jordan and Jack, he's had a terrible day, and has to then take over parenting duties by telling his son a bedtime story.
Cox's fairytale begins with the usual suspects lined up and dressed for the occasion. Once upon a time on the outskirts of a village called Sacred Heartily, Princess Elliot needed help with her maid Marion. The village idiot, J.D., arrives to assist, bragging of his bravery in saving a fish from drowning. The Princess explains that her Maid Marion is suffering from a monster disease. Turkala, a two headed witch, then appears, offering help. The witch tells the Princess and the idiot to meet her at the village drug store for a magic potion.
The story continues as the idiot and the Princess ride to the village on a mule where the Dark Lord Oslek appears and warns, "Everyone who enters the forbidden forest shall disappear!" Back in the hospital, Doug stays longer than his shift and is "banished" home without pay. Elliot and J.D. ask Turk and Carla if the lab results for Marion are back. Carla has worked some magic and hands the results over รข€" they are negative. Elliot still doesn't know what is wrong with Marion.
Back in the story, Princess Elliot uses a dove to "page" her handsome Knight Percival Cox. Her savior arrives and fights the monster disease with his sword but is foiled when the witch Jordan interrupts and turns out the light. Unable to finish the story, Cox sneaks back into Jack's room to complete the adventure. The knight Cox is defeated by the monster disease, but tells the Princess and the idiot the monster can only be vanquished by a gold ring.
In the forbidden forest the giant tells Princess Elliot and J.D. the Idiot that evil Oslek will catch them as he is near. In the hospital, J.D. and Elliot are hiding from Kelso after their shift ends, but he catches them and banishes them to his office where he threatens to suspend them. Back in the forest, the Princess and the Idiot look for the gold ring but can't find it.
J.D. remembers the interns playing diagnosis Jeopardy. The answer to their quiz is the answer to Maid Marion's disease. The Princess and Idiot find the gold ring and race through the village to save Maid Marion. Back at Sacred Heart, J.D. examines Marion's eyes. Seeing a gold ring around her retina, he diagnoses Wilson's Disease. They are now able to treat her and all hopefully live happily ever after.
